Structure of PDB 7du4 Chain B Binding Site BS01

Receptor Information
>7du4 Chain B (length=106) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEPRRGDLWLVSLGGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTP
LRPPVAPSEGVAADSVAVCRGVRAVARARLVERLGALKPATMRAIENALT
LILGLP
Ligand information
>7du4 Chain Q (length=10) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EWEGTVGDGL
Receptor-Ligand Complex Structure
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PDB7du4 Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins.
Resolution2.18 Å
Binding residue
(original residue number in PDB)		L14 P49 R81
Binding residue
(residue number reindexed from 1)		L13 P41 R73
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
Biological Process
GO:0006402 mRNA catabolic process
GO:0016075 rRNA catabolic process
GO:0017148 negative regulation of translation
GO:0044003 symbiont-mediated perturbation of host process
GO:0045926 negative regulation of growth

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Molecular Function
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Biological Process
External links
PDB RCSB:7du4, PDBe:7du4, PDBj:7du4
PDBsum7du4
PubMed33925254
UniProtP0CL62|MAZF7_MYCTU Probable endoribonuclease MazF7 (Gene Name=mazF7)

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