Structure of PDB 7das Chain B Binding Site BS01

Receptor Information

>7das Chain B (length=671) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

YFQSQCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFT
RYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFC
TNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLEN
LQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGK
LFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLK
WTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLS
NLRYLSLKRAFTKQSASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTF
TGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANG
TFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSS
FALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDL
LEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLD
EIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSV
EKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHY
LCNTPHHYYGFPLKLFDTSSC

Ligand information

>7das Chain C (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ugaaggccuguuuccuaggcuacauacgagggaccgcaccaaccacacgg
ggcucauucucagcgc

<...<<..<<..<<<..<......<...............>......>.>
>>..>>..>>....>.

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7das Endosomal lncRNA Rmrp is required for TLR3 innate sensing by engaging TLR3 dimerization
Resolution	3.64 Å
Binding residue (original residue number in PDB)	H40 K42 H61 Q63 F85 N86 S87 S89 H109 E111 R490 N516 N518 A520 H540 N542 G574
Binding residue (residue number reindexed from 1)	H17 K19 H38 Q40 F62 N63 S64 S66 H86 E88 R464 N490 N492 A494 H514 N516 G548

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7das, PDBe:7das, PDBj:7das
PDBsum	7das
PubMed
UniProt	Q99MB1\|TLR3_MOUSE Toll-like receptor 3 (Gene Name=Tlr3)

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