Structure of PDB 7d3c Chain B Binding Site BS01

Receptor Information
>7d3c Chain B (length=299) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDDTVWCPRHVMCPADQLS
DPNYDALLISMTNHSFSVQKHANLRVVGHAMQGTLLKLTVDVANPSTPAY
TFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGSVGYT
KEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYCS
VNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDML
AVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQIMGV
Ligand information
Receptor-Ligand Complex Structure
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PDB7d3c The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H41 F143 G146 S147 C148 H166 M168 E169 Q192 V193
Binding residue
(residue number reindexed from 1)		H41 F139 G142 S143 C144 H162 M164 E165 Q188 V189
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7d3c, PDBe:7d3c, PDBj:7d3c
PDBsum7d3c
PubMed23549610
UniProtK9N7C7|R1AB_MERS1 Replicase polyprotein 1ab (Gene Name=rep)

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