Structure of PDB 7cq2 Chain B Binding Site BS01

Receptor Information
>7cq2 Chain B (length=297) Species: 307796 (Saccharomyces cerevisiae YJM789) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIQQHQFPDFYCCYLLQSINKRQSFYVGSTPNPVRRLRQHNGKLAVGGAY
RTKRDGSRPWEMIMIVRGFPSKIAALQFEHAWQHGYQTHYIAEKDRVVKH
KAGGRTLHHKVALMKLLLKHEFFQRMNLIVEVFNIKAWEVWKQDKFFIER
DRFPINIQINENALEEPKEKTVDVLMDHSDENLKVVEAVYTKVIENERNI
FETFEKKLTTGVVRCEICEKEIDYTSENLKPFVALCNNKDCGCVNHLKCL
HRYFLDDEQLIVGRRNLIPRGGKCPKCDMFCDWTTLVKFSTRMKLAH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7cq2 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7cq2 Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		C218 H251 C254
Binding residue
(residue number reindexed from 1)		C215 H246 C249
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008821 crossover junction DNA endonuclease activity
GO:0017108 5'-flap endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:1902681 regulation of replication fork arrest at rDNA repeats
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0000228 nuclear chromosome
GO:0005634 nucleus
GO:0033557 Slx1-Slx4 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cq2, PDBe:7cq2, PDBj:7cq2
PDBsum7cq2
PubMed34181713
UniProtP38324|SLX1_YEAST Structure-specific endonuclease subunit SLX1 (Gene Name=SLX1)

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