Structure of PDB 7cmi Chain B Binding Site BS01

Receptor Information
>7cmi Chain B (length=458) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGA
LCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIAL
TFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF
TAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQ
GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTA
MSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRL
FFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINY
VGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVF
SLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKM
CVVVYPEV
Ligand information
Ligand IDLEU
InChIInChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKeyROHFNLRQFUQHCH-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)C[C@@H](C(=O)O)N
CACTVS 3.341CC(C)C[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CC(C)CC(C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CC(C)C
CACTVS 3.341CC(C)C[CH](N)C(O)=O
FormulaC6 H13 N O2
NameLEUCINE
ChEMBLCHEMBL291962
DrugBankDB00149
ZINCZINC000003645145
PDB chain7cmi Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7cmi Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		I53 G55 G57 N134 F243 G246
Binding residue
(residue number reindexed from 1)		I13 G15 G17 N94 F203 G206
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015101 organic cation transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015180 L-alanine transmembrane transporter activity
GO:0015187 glycine transmembrane transporter activity
GO:0015190 L-leucine transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015349 thyroid hormone transmembrane transporter activity
GO:0019534 toxin transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042605 peptide antigen binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006865 amino acid transport
GO:0015804 neutral amino acid transport
GO:0015807 L-amino acid transport
GO:0015816 glycine transport
GO:0015820 L-leucine transport
GO:0015827 tryptophan transport
GO:0015829 valine transport
GO:0035524 proline transmembrane transport
GO:0055085 transmembrane transport
GO:0070327 thyroid hormone transport
GO:0089718 amino acid import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1903801 L-leucine import across plasma membrane
GO:1904273 L-alanine import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031528 microvillus membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cmi, PDBe:7cmi, PDBj:7cmi
PDBsum7cmi
PubMed33298890
UniProtQ9UHI5|LAT2_HUMAN Large neutral amino acids transporter small subunit 2 (Gene Name=SLC7A8)

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