Structure of PDB 7brh Chain B Binding Site BS01

Receptor Information
>7brh Chain B (length=426) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVL
GSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHW
RVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA
LVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLL
RAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKS
AQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLL
ADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQ
RMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQE
LMAVSEHKLYWPLGYPPPDVPKCGFD
Ligand information
>7brh Chain L (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RSSCFGGRMDRIGAQSGLGCNSFRY
Receptor-Ligand Complex Structure
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PDB7brh Structural insight into hormone-recognition and transmembrane signaling by the atrial natriuretic peptide receptor
Resolution2.45 Å
Binding residue
(original residue number in PDB)		Y88 G113 Y120 L158 D160 R162 F165 E169 Y172 H185 Q186 E187 V189 H195 K198
Binding residue
(residue number reindexed from 1)		Y88 G113 Y120 L158 D160 R162 F165 E169 Y172 H185 Q186 E187 V189 H195 K198
Enzymatic activity
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7brh, PDBe:7brh, PDBj:7brh
PDBsum7brh
PubMed
UniProtP18910|ANPRA_RAT Atrial natriuretic peptide receptor 1 (Gene Name=Npr1)

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