Structure of PDB 7bre Chain B Binding Site BS01

Receptor Information
>7bre Chain B (length=163) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEM
VIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARF
INHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDAKLP
CNCGAKRCRRFLN
Ligand information
>7bre Chain C (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FKELDENVEYEERESEFDIE
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bre Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.
Resolution2.803 Å
Binding residue
(original residue number in PDB)		K2570 S2605 G2606 I2607 V2608 I2609 R2610 L2613 K2616 M2643 H2644 G2645 R2649
Binding residue
(residue number reindexed from 1)		K20 S55 G56 I57 V58 I59 R60 L63 K66 M93 H94 G95 R99
Enzymatic activity
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:7bre, PDBe:7bre, PDBj:7bre
PDBsum7bre
PubMed32697937
UniProtQ9UMN6|KMT2B_HUMAN Histone-lysine N-methyltransferase 2B (Gene Name=KMT2B)

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