Structure of PDB 7bik Chain B Binding Site BS01

Receptor Information
>7bik Chain B (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSM
NGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRW
IFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDTV8
InChIInChI=1S/C12H17N5O4/c1-13-10-7-11(15-4-14-10)17(5-16-7)12-9(20-2)8(19)6(3-18)21-12/h4-6,8-9,12,18-19H,3H2,1-2H3,(H,13,14,15)/t6-,8+,9-,12-/m1/s1
InChIKeyGRYSXUXXBDSYRT-IQEPQDSISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CNc1c2c(ncn1)n(cn2)C3C(C(C(O3)CO)O)OC
OpenEye OEToolkits 2.0.7CNc1c2c(ncn1)n(cn2)[C@H]3[C@@H]([C@H]([C@H](O3)CO)O)OC
CACTVS 3.385CNc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](O)[C@H]3OC
CACTVS 3.385CNc1ncnc2n(cnc12)[CH]3O[CH](CO)[CH](O)[CH]3OC
FormulaC12 H17 N5 O4
Name(2~{R},3~{S},4~{R},5~{R})-2-(hydroxymethyl)-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-ol
ChEMBL
DrugBank
ZINC
PDB chain7bik Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bik Crystal structure of YTHDF2 in complex with m6Am
Resolution2.1 Å
Binding residue
(original residue number in PDB)		K416 S417 Y418 D422 W432 C433 W486 W491 D528
Binding residue
(residue number reindexed from 1)		K17 S18 Y19 D23 W33 C34 W87 W92 D129
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7bik, PDBe:7bik, PDBj:7bik
PDBsum7bik
PubMed
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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