Structure of PDB 7b4a Chain B Binding Site BS01

Receptor Information
>7b4a Chain B (length=195) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPV
QLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCLAPPQHLIRVE
GNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNR
RPILTIITLEDSSGNLLGRNSFEVHVCACPGRDRRTEEENLRKKG
Ligand information
Receptor-Ligand Complex Structure
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PDB7b4a Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Resolution1.9 Å
Binding residue
(original residue number in PDB)		S241 H273 C275 A276 R280
Binding residue
(residue number reindexed from 1)		S143 H175 C177 A178 R182
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b4a, PDBe:7b4a, PDBj:7b4a
PDBsum7b4a
PubMed34862374
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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