Structure of PDB 7aud Chain B Binding Site BS01

Receptor Information
>7aud Chain B (length=513) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFI
LMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYL
TGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERK
LLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRV
QKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHP
YDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQ
DGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEIS
HCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECR
RIQLLAYFGENGFNPDFCKKHPDVSCDNCCSQREEMVKKCLGELTEVCKS
LGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEV
ISVLQKYSEWTSP
Ligand information
Receptor-Ligand Complex Structure
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PDB7aud Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Resolution2.96 Å
Binding residue
(original residue number in PDB)
R717 T738 G739 T766 E768 K769 S773 N774 R775 F807 R808 L896 S897 R898 H919 A920 T946 I947 K968 R1003 M1007 E1008
Binding residue
(residue number reindexed from 1)
R80 T101 G102 T129 E131 K132 S136 N137 R138 F170 R171 L259 S260 R261 H282 A283 T309 I310 K331 R366 M370 E371
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination
GO:0044237 cellular metabolic process

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Molecular Function

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Biological Process
External links
PDB RCSB:7aud, PDBe:7aud, PDBj:7aud
PDBsum7aud
PubMed33647232
UniProtP54132|BLM_HUMAN RecQ-like DNA helicase BLM (Gene Name=BLM)

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