Structure of PDB 7age Chain B Binding Site BS01

Receptor Information

>7age Chain B (length=339) Species: 5480 (Candida parapsilosis)

DSISLSLINEGPSYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNAQCGKG
VDCKSSGTFTPSSSSSYKNLGAAFTIRYGDGSTSQGTWGKDTVTINGVSI
TGQQIADVTQTSVDQGILGIGYTSNEAVYDTSGRQTTPNYDNVPVTLKKQ
GKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTSSQALTIS
LASVNLKGSSFSFGDGALLDSGTTLTYFPSDFAAQLADKAGARLVQVARD
QYLYFIDCNTDTSGTTVFNFGNGAKITVPNTEYVYQNGDGTCLWGIQPSD
DTILGDNFLRHAYLLYNLDANTISIAQVKYTTDSSISAV

Ligand information

>7age Chain C (length=5) Species: 32630 (synthetic construct)

VVYAY

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7age Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .
• Resolution: 1.3 Å
• Binding residue (original residue number in PDB): I30 D32 G34 Y78 G79 D80 V113 I117 L218 D220 G222 T223 T224 Y227 Y285 D301 I303
• Binding residue (residue number reindexed from 1): I30 D32 G34 Y78 G79 D80 V113 I117 L218 D220 G222 T223 T224 Y227 Y285 D301 I303

Enzymatic activity

• Catalytic site (original residue number in PDB): D32 S35 D37 W39 Y78 D220 T223
• Catalytic site (residue number reindexed from 1): D32 S35 D37 W39 Y78 D220 T223
• Enzyme Commision number: 3.4.23.24: candidapepsin.

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:7age, PDBe:7age, PDBj:7age
• PDBsum: 7age
• PubMed: 33843395
• UniProt: P32951|CARP1_CANPA Candidapepsin-1 (Gene Name=SAPP1)