Structure of PDB 7a6h Chain B Binding Site BS01

Receptor Information
>7a6h Chain B (length=1097) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTS
DADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDI
EYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGG
YFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMA
VKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGP
SLEECQKAQIFTQMQALKYIGNKVRRQKTKIEEARELLASTILTHVPVKE
FNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNKRLELAGQLLSLLFED
LFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS
LKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQ
WGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNL
LCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSIS
TNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFL
HESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYP
HHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTI
ELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNA
KCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQ
VLVNKSMPTVTQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLL
RQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFP
SRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLG
KDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQP
TEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGL
LGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7a6h Chain B Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a6h Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C1080 C1083 C1092 C1095
Binding residue
(residue number reindexed from 1)		C1045 C1048 C1057 C1060
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042796 snRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a6h, PDBe:7a6h, PDBj:7a6h
PDBsum7a6h
PubMed33558764
UniProtQ9NW08|RPC2_HUMAN DNA-directed RNA polymerase III subunit RPC2 (Gene Name=POLR3B)

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