Structure of PDB 6zxv Chain B Binding Site BS01

Receptor Information
>6zxv Chain B (length=323) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSMKFLFYLSADNLEIARKEVLVLAERYGWVEDYQFEERLLLLDYAGEKF
FERLAYTNEVTKIYDICSVSELEQVFSEIPVYDRLCCVRVKGGKGKTALE
RKLGALLWKRGAKVSVSNPEIVYKVYIQDDKCYVGLLEFERDTRQFFLRR
PDRRPFLMPSAIKPKLARALVNLTGVLEGETLLDPMCGTGSFLIEAGLMG
INPIGIDFIEKIVRGCRVNLEYYGIEGSVLLGDAKNLPLRDESVRGIATD
YPYLRSTKAAGTLDELYSKTSEEFERVLKKGGRAAIVTNIDVESFFSNFE
IEMKTEERVHGSLTRRIYLLRRH
Ligand information
Ligand IDSFG
InChIInChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
InChIKeyLMXOHSDXUQEUSF-YECHIGJVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)C[C@H](CC[C@@H](C(=O)O)N)N)O)O)N
OpenEye OEToolkits 1.7.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O)N
CACTVS 3.370N[CH](CC[CH](N)C(O)=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
CACTVS 3.370N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
ACDLabs 12.01O=C(O)C(N)CCC(N)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O
FormulaC15 H23 N7 O5
NameSINEFUNGIN;
ADENOSYL-ORNITHINE
ChEMBLCHEMBL1214186
DrugBankDB01910
ZINCZINC000004217451
PDB chain6zxv Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6zxv Functional and structural characterization of the Trm11-Trm112 m2G10 tRNA methyltransferase complex
Resolution1.88 Å
Binding residue
(original residue number in PDB)		M184 D205 F206 I210 D231 A232 D248 Y249 P250 Y251 R253
Binding residue
(residue number reindexed from 1)		M186 D207 F208 I212 D233 A234 D250 Y251 P252 Y253 R255
Annotation score3
Enzymatic activity
Enzyme Commision number 2.1.1.213: tRNA (guanine(10)-N(2))-dimethyltransferase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0016423 tRNA (guanine) methyltransferase activity
GO:0016740 transferase activity
GO:0160101 tRNA (guanine(10)-N2)-dimethyltransferase activity
GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity
Biological Process
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zxv, PDBe:6zxv, PDBj:6zxv
PDBsum6zxv
PubMed
UniProtO29011|TMG10_ARCFU tRNA (guanine(10)-N2)-dimethyltransferase (Gene Name=trmG10)

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