Structure of PDB 6zgr Chain B Binding Site BS01

Receptor Information

>6zgr Chain B (length=364) Species: 335543 (Syntrophobacter fumaroxidans MPOB)

WVPLLLGLLGSTTCGMLLYAWSVFIKPLNAEFSRAEIAMAFAICCLIFGL
MTFPAGRLSDKMGPRKVVMTGGVLLAIGFILSGFIQSKYQLYITYGVIAG
FGGGMIYLPPIATAPKWWPDRRALATGFAVVGLGLGSFLMGPLATYIIGW
RYVFWYCGVAMGIMALIAGAFLEPDWTYEEAKGDTKFWLLYLAYFCGSFA
GLMVIGHLAGFGRDAGLTAMAAAGAVSSLAFSNAATRILSGWFVDKIGIR
VYFAALFALQTAAMIAIFQLGGSVVGLSIVAIVIGWNYGAMFTLFPATCL
QFYGPTAQGSNYGLLFTACGLAGFAGPWVGGWLKDTTGTYYLPFLCAAAL
CALGTAIVFMTKPP

Ligand information

• Ligand ID: 1HN
• InChI: InChI=1S/C11H8O3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H,(H,13,14)
• InChIKey: SJJCQDRGABAVBB-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.7.0: c1ccc2c(c1)ccc(c2O)C(=O)O
  ACDLabs 12.01: O=C(O)c2ccc1ccccc1c2O
  CACTVS 3.370: OC(=O)c1ccc2ccccc2c1O
• Formula: C11 H8 O3
• Name: 1-hydroxynaphthalene-2-carboxylic acid
• ChEMBL: CHEMBL229299
• ZINC: ZINC000000037856
• PDB chain: 6zgr Chain B Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zgr The making of a potent L-lactate transport inhibitor
• Resolution: 2.46 Å
• Binding residue (original residue number in PDB): F60 Y119 L145 R280 Y331 F335 F359
• Binding residue (residue number reindexed from 1): F48 Y107 L133 R237 Y288 F292 F316
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0015293 symporter activity
• GO:0022857 transmembrane transporter activity

Biological Process

• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:6zgr, PDBe:6zgr, PDBj:6zgr
• PDBsum: 6zgr
• UniProt: A0LNN5|SFMCT_SYNFM L-lactate transporter (Gene Name=Sfum_3364)