Structure of PDB 6z7t Chain B Binding Site BS01

Receptor Information
>6z7t Chain B (length=730) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVSDKRYIWYNPDPKERDSYECGEIVSETSDSFTFKTVDGQDRQVKKDDA
NQRNPIKFDGVEDMSELSYLNEPAVFHNLRVRYNQDLIYTYSGLFLVAVN
PFKRIPIYTQEMVDIFKGRRRNEVAPHIFAISDVAYRSMLDDRQNQSLLI
TGESGAGKTENTKKVIQYLASVAGRNNGSGVLEQQILQANPILEAFGNAK
TTRNNNSSRFGKFIEIQFNSAGFISGASIQSYLLEKSRVVFQSETERNYH
IFYQLLAGATAEEKKALHLAGPESFNYLNQSGCVDIKGVSDSEEFKITRQ
AMDIVGFSQEEQMSIFKIIAGILHLGNIKFEKGAGEGAVLKDKTALNAAS
TVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRDALVKALYGRL
FLWLVKKINNVLCQERKAYFIGVLDISGFEIFKVNSFEQLCINYTNEKLQ
QFFNHHMFKLEQEEYLKEKINWTFIDFGLDSQATIDLIDGRQPPGILALL
DEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKTEFGVTHYAGQVMY
EIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLFNDPNFITVAAQYKEQLA
SLMATLETTNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITR
KGFPNRIIYADFVKRYYLLAPNVPRDAEDSQKATDAVLKHLNIDPEQYRF
GITKIFFRAGQLARIEEAREQRLESNEPPM
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6z7t Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6z7t Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke.
Resolution1.88 Å
Binding residue
(original residue number in PDB)		G179 E180 S181 A183 K185
Binding residue
(residue number reindexed from 1)		G152 E153 S154 A156 K158
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S181 G182 T186 N233 S236 S237 G457 E459
Catalytic site (residue number reindexed from 1) S154 G155 T159 N204 S207 S208 G428 E430
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:6z7t, PDBe:6z7t, PDBj:6z7t
PDBsum6z7t
PubMed33049993
UniProtP08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA)

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