Structure of PDB 6ycs Chain B Binding Site BS01

Receptor Information
>6ycs Chain B (length=67) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNMFQIGKMRYVSVRDFKGKVLIDIREYWMDPEGEMKPGRKGISLNPEQW
SQLKEQISDIDDAVRKL
Ligand information
Receptor-Ligand Complex Structure
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PDB6ycs Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		F77 L82 R86 W89 P98 G99 R100 K101
Binding residue
(residue number reindexed from 1)		F17 L22 R26 W29 P38 G39 R40 K41
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0060261 positive regulation of transcription initiation by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:6ycs, PDBe:6ycs, PDBj:6ycs
PDBsum6ycs
PubMed32202774
UniProtP53999|TCP4_HUMAN Activated RNA polymerase II transcriptional coactivator p15 (Gene Name=SUB1)

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