Structure of PDB 6y0c Chain B Binding Site BS01

Receptor Information
>6y0c Chain B (length=686) Species: 100673 (Influenza C virus (C/Johannesburg/1/66)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEINPYLMFLNNDVTSLISTTYPYTGPPPSTKYTLETIKRTYDYSRTSVE
KTSKVFNIPRRKFCNCLEDKDELVKPTGNVDISSLLGLAEMMEKRMGEGF
FKHCVMEAETEILKMHFSRLTEGRQTYDWTSERNMPAATALQLTVDAIKE
TEGPFKGTTMLEYCNKMIEMLDWKEIKFKKVIDSIKHDEFLIRALTINTM
AKAIATPGMIVRPFSKIVETVAQKICEKLKESGLPVGGNEKKAKLKTTVT
SLNARMNSDQFAVNITGDNSKWNECQQPEAYLALLAYITKDSSDLMKDLC
SVAPVLFCNKFVKLGQGIRLSNKRKTKEVIIKAEKMGKYKNLMREEYKNL
FEPLEKYIQKDVCFLPGGMLMGMFNMLSTVLGVSTLCYMDEELKAKGCFW
TGLQSSDDFVLFAVASNWSNIHWTIRRFNAVCKLIGINMSLEKSYGSLPE
LFEFTSMFFDGEFVSNLAMELPAFTTAGVNEGVDFTAAMSIIKTNMINNS
LSPSTALMALRICLQEFRATYRVHPWDSRVKGGRMKIINEFIKTIENKDG
LLIADGGKLMNNISTLHIPEEVLKFEKMDEQYRNRVFNPKNPFTNEAVVS
THSFRTMRAMMAEEKRYQMVCDMFKSVFESADINPPIGAMSIGEAIEEKL
LERAKMKRDIGAIEDSEYEEIKDIIRDAKKARLESR
Ligand information
>6y0c Chain IN1 (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguagaaacaagggccuuuu
.<<....>>.<<<.>>>...
Receptor-Ligand Complex Structure
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PDB6y0c Host ANP32A mediates the assembly of the influenza virus replicase.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S35 Q355 R358 K570 G571
Binding residue
(residue number reindexed from 1)		S30 Q316 R319 K531 G532
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6y0c, PDBe:6y0c, PDBj:6y0c
PDBsum6y0c
PubMed33208942
UniProtQ9IMP4|RDRP_INCJH RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)

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