Structure of PDB 6xie Chain B Binding Site BS01

Receptor Information
>6xie Chain B (length=277) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIPWNLERITPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEED
ASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLE
FIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFR
DDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDII
GASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFS
AKDVINEAWFPEDQRVLTPNLVAALPP
Ligand information
Receptor-Ligand Complex Structure
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PDB6xie Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
Resolution1.43 Å
Binding residue
(original residue number in PDB)		S153 P155 D238 I369 T377 C378 F379 V380 S381
Binding residue
(residue number reindexed from 1)		S1 P3 D69 I200 T208 C209 F210 V211 S212
Enzymatic activity
Catalytic site (original residue number in PDB) D186 H226 N317 S386
Catalytic site (residue number reindexed from 1) D24 H57 N148 S217
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6xie, PDBe:6xie, PDBj:6xie
PDBsum6xie
PubMed33170686
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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