Structure of PDB 6xib Chain B Binding Site BS01

Receptor Information
>6xib Chain B (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIPWNLERITPPQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVP
EEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKG
TVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGV
VLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCV
DLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLA
ELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPP
Ligand information
Receptor-Ligand Complex Structure
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PDB6xib Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
Resolution1.546 Å
Binding residue
(original residue number in PDB)		S153 P155 W156 D238 I369 D374 T377 C378 F379 V380 S381
Binding residue
(residue number reindexed from 1)		S1 P3 W4 D79 I210 D215 T218 C219 F220 V221 S222
Enzymatic activity
Catalytic site (original residue number in PDB) D186 H226 N317 S386
Catalytic site (residue number reindexed from 1) D27 H67 N158 S227
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6xib, PDBe:6xib, PDBj:6xib
PDBsum6xib
PubMed33170686
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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