Structure of PDB 6x1b Chain B Binding Site BS01
Receptor Information
>6x1b Chain B (length=346) Species:
2697049
(Severe acute respiratory syndrome coronavirus 2) [
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SLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLP
VNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIG
VCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKG
LQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNL
QEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHL
LIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLD
DFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQ
Ligand information
>6x1b Chain F (length=2) [
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gu
..
Receptor-Ligand Complex Structure
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PDB
6x1b
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Resolution
1.97 Å
Binding residue
(original residue number in PDB)
Q245 K290 V292 S294 W333 T341 Y343 K345
Binding residue
(residue number reindexed from 1)
Q244 K289 V291 S293 W332 T340 Y342 K344
Enzymatic activity
Enzyme Commision number
2.1.1.56
: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57
: methyltransferase cap1.
2.7.7.48
: RNA-directed RNA polymerase.
2.7.7.50
: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12
: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69
: SARS coronavirus main proteinase.
3.6.4.12
: DNA helicase.
3.6.4.13
: RNA helicase.
4.6.1.-
External links
PDB
RCSB:6x1b
,
PDBe:6x1b
,
PDBj:6x1b
PDBsum
6x1b
PubMed
33564093
UniProt
P0DTD1
|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)
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