Structure of PDB 6wpg Chain B Binding Site BS01

Receptor Information
>6wpg Chain B (length=106) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEPSKYRLCIDILEREIRRNPTCSHSMPEDLQMRLLYLEKRVGLAQLFF
PAEANVAMDVANVTPYVQTKRMLTRMKALMKTVETGRRYFPSCYEVLDKY
MDQYMD
Ligand information
Ligand IDSAL
InChIInChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
InChIKeyYGSDEFSMJLZEOE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)c1ccccc1O
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)O)O
CACTVS 3.341OC(=O)c1ccccc1O
FormulaC7 H6 O3
Name2-HYDROXYBENZOIC ACID;
SALICYLIC ACID
ChEMBLCHEMBL424
DrugBankDB00936
ZINCZINC000000001554
PDB chain6wpg Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wpg Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
Resolution2.283 Å
Binding residue
(original residue number in PDB)		R419 A423 A431 A434 V489 G492 Y500 L503
Binding residue
(residue number reindexed from 1)		R42 A46 A54 A57 V83 G86 Y94 L97
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0009862 systemic acquired resistance, salicylic acid mediated signaling pathway
GO:2000022 regulation of jasmonic acid mediated signaling pathway
GO:2000031 regulation of salicylic acid mediated signaling pathway

View graph for
Biological Process
External links
PDB RCSB:6wpg, PDBe:6wpg, PDBj:6wpg
PDBsum6wpg
PubMed32788727
UniProtQ5ICL9|NPR4_ARATH Regulatory protein NPR4 (Gene Name=NPR4)

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