Structure of PDB 6whg Chain B Binding Site BS01

Receptor Information
>6whg Chain B (length=523) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFEAPTPRQILRVTLNLKYLIDKVVPIVYILSPKVVKLAYEACGGNPKDK
ANKRKYQSVIIFSLLKVCEWYSILATMEVHNAKLYETRNLASQQLCKLLI
EREETRDLQFLFMQLLLRRYVINENDEDQEPLNALELATDMHCTTVIGSS
GFQRCLKWIWRGWIVQNGLDPTTFIKDDSLAFNPVRLKAPVYQNYLQMIF
SFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGY
AHLSFWNLFNDTTYLIITFAMGFRAMSVTPYSSEDWDKISYRVLSCAAPF
VWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLIMIGFTQGFLGL
DSADGKRDITGPILGNLTITVLGLGSFDVFEEFAPPYAAILYYGYYFIVS
VILLNILIALYSTAYQKVIDNADDEYMALMSQKTLRYIRKDLSYTVMTIV
YSPFLLLISVKETREARRIKYNRMKRLNDDANEYDTPWDLTDGYLDDNRN
SGMRATQLKNSRSLKLQRTAEQE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6whg Chain B Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6whg Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D398 D401 K403 D405
Binding residue
(residue number reindexed from 1)		D351 D354 K356 D358
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
Biological Process
GO:0030003 intracellular monoatomic cation homeostasis
GO:0035725 sodium ion transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:0097553 calcium ion transmembrane import into cytosol
Cellular Component
GO:0000324 fungal-type vacuole
GO:0000329 fungal-type vacuole membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:1990816 vacuole-mitochondrion membrane contact site

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6whg, PDBe:6whg, PDBj:6whg
PDBsum6whg
PubMed34453887
UniProtQ12324|YVC1_YEAST Calcium channel YVC1 (Gene Name=YVC1)

[Back to BioLiP]