Structure of PDB 6w8w Chain B Binding Site BS01

Receptor Information
>6w8w Chain B (length=826) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLAR
VTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYI
HSKVKVIYKAPSENWAMEGGYFFQLWYNQEYARFESPPKTQPTEDNKHKF
CLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSVYLP
PEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDAPEPYR
IGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDINMLY
WSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYNSKT
KNFEDPPNHARSPGNIKLPKLRTLDVFSGCGGLSEGFHQAGISETLWAIE
MWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGDVE
MLCGGPPCQGFSGMNRFNYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNF
VSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPG
EKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTM
SDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSPLV
AARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGA
LRGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWDGF
FSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFGNILDR
HRQVGNAVPPPLAKAIGLEIKLCLLS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w8w DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G1234 M1235 R1237 Q1343 R1492 C1501 H1504 T1505 R1508 H1509 W1512 E1533
Binding residue
(residue number reindexed from 1)		G463 M464 R466 Q569 R718 C727 H730 T731 R734 H735 W738 E759
Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C458 E495 R539 R541
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6w8w, PDBe:6w8w, PDBj:6w8w
PDBsum6w8w
PubMed
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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