Structure of PDB 6w2y Chain B Binding Site BS01

Receptor Information
>6w2y Chain B (length=664) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIH
HDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVL
SYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQT
TEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGL
FYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEM
TEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQ
EAPLAYDAIWALALALNKTSRLEDFNYNNQTITDQIYRAMNSSSFEGVSG
HVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSP
PADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQ
NSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLG
FSLGYGSMFTKIWWVHTVFWKLYATVGLLVGMDVLTLAIWQIVDPLHRTI
ETFAKEEPDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETK
SVNDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYI
TLVVLFVPKMRRLI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6w2y Chain B Residue 905 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6w2y Structures of metabotropic GABABreceptor.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G277 E309
Binding residue
(residue number reindexed from 1)		G229 E261
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004965 G protein-coupled GABA receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w2y, PDBe:6w2y, PDBj:6w2y
PDBsum6w2y
PubMed32580208
UniProtQ9UBS5|GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (Gene Name=GABBR1)

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