Structure of PDB 6vzy Chain B Binding Site BS01

Receptor Information
>6vzy Chain B (length=460) Species: 285532 (Streptomyces achromogenes subsp. streptozoticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPPHVPFELSGAELRDAIVQYATNPIYHDNLDWLNHDNPYRRQLRPQVLP
HLDYDKVPGRENILNYASLAVQRLLTSVYEADLVFFPKSGLKGKEEDFRA
FYSPANRALGERIRPALERYAFGFLDDEVEGTWTAQSLDAYLDSLEQSPV
EKAILGSADRERAARMWLVQFAPDFLSEASPMMRNVLGYYGPAQSEWFKV
VIDEYGYGVHDTKHSTLFERTLESVGLESDLHRYWQYYLNSSLLLNNYFH
YLGKNHELFFRYVGALYYTESSLVDFCRRADHLLREVFGDTVDTTYFTEH
IHIDQHHGRMAREKIIKPLVEAHGDGIIPEIVRGIEEYRVLLEIGDFDFS
EQIAWMDAQPELKKLHDPVFEGLKQGKVDAPVAHLVEPRGELSNTHCHDG
DELCHIVSGTMRFESGLGSSLTLQAGEGVVIKRNRLHGANIESDECVYEI
HSVGDYRKCL
Ligand information
Ligand IDFE2
InChIInChI=1S/Fe/q+2
InChIKeyCWYNVVGOOAEACU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Fe+2]
CACTVS 3.341[Fe++]
FormulaFe
NameFE (II) ION
ChEMBL
DrugBankDB14510
ZINC
PDB chain6vzy Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vzy Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the N -nitrosourea-producing enzyme SznF.
Resolution1.66 Å
Binding residue
(original residue number in PDB)		E189 E215 H225 H311
Binding residue
(residue number reindexed from 1)		E178 E204 H214 H300
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.13.250: nitrosourea synthase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6vzy, PDBe:6vzy, PDBj:6vzy
PDBsum6vzy
PubMed33468680
UniProtA0A411MR89|SZNF_STRC2 Nitrosourea synthase (Gene Name=sznF)

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