Structure of PDB 6vff Chain B Binding Site BS01

Receptor Information
>6vff Chain B (length=436) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLA
KARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGK
FGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMS
DRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGF
RLKENVQFHLYISTSPCGDARIFSPHEARGQLRTKIESGQGTIPVRSLTM
SCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRI
SNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINA
TTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLA
AKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>6vff Chain C (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcucgcgaugcuggagggcucugauagcuacg
................................
Receptor-Ligand Complex Structure
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PDB6vff Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S258 K261 F263 R279 N280 K281
Binding residue
(residue number reindexed from 1)		S24 K27 F29 R45 N46 K47
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:6vff, PDBe:6vff, PDBj:6vff
PDBsum6vff
PubMed32597966
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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