Structure of PDB 6v64 Chain B Binding Site BS01

Receptor Information
>6v64 Chain B (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
QF
Ligand information
>6v64 Chain A (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYIDG
Receptor-Ligand Complex Structure
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PDB6v64 19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2.
Resolution2.29 Å
Binding residue
(original residue number in PDB)
E23 I24 G25 M26 P28 X29 D116 H119 P120 C122 Y134 K135 R137 N159 K202 R206 X207
Binding residue
(residue number reindexed from 1)
E8 I9 G10 M11 P13 X14 D113 H116 P117 C119 Y134 K135 R137 N159 K207 R213 X214
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E197 G198 D199 S200 G201
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function

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Biological Process
External links
PDB RCSB:6v64, PDBe:6v64, PDBj:6v64
PDBsum6v64
PubMed32358061
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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