Structure of PDB 6v5b Chain B Binding Site BS01

Receptor Information
>6v5b Chain B (length=216) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVQDKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGAS
VTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQSEELEYFNHISI
EDSRVYELTSKAGLLSPYQILHECLKRNHGMGDTSIKFEQKSEYVMACGK
HTVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGREKPNLHILS
KLQEEMKRLAEEREET
Ligand information
>6v5b Chain D (length=78) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacauacuuguuccacucuagcagcacguaaauauuggcaccaauauuac
ugugcugcuuuagugugacagggauaca
<.....<<<<<<.<<<<..<<<<<<<<<..<<<<<<<<..>>>>>>>>..
>>>>>>>>>..>>>>.>>>>>>....>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6v5b Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		F503 C514 H517 R522 R527 K561 K562
Binding residue
(residue number reindexed from 1)		F8 C19 H22 R27 R32 K66 K67
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0020037 heme binding
GO:0042802 identical protein binding
Biological Process
GO:0031053 primary miRNA processing
Cellular Component
GO:0070877 microprocessor complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6v5b, PDBe:6v5b, PDBj:6v5b
PDBsum6v5b
PubMed32220646
UniProtQ8WYQ5|DGCR8_HUMAN Microprocessor complex subunit DGCR8 (Gene Name=DGCR8)

[Back to BioLiP]