Structure of PDB 6v1a Chain B Binding Site BS01
Receptor Information
>6v1a Chain B (length=173) Species:
9606
(Homo sapiens) [
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DTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVT
ELGRPDAEYWNSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVTV
YPAKTVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWTFQTLVM
LETEVYTCQVEHPSLTSPLTVEW
Ligand information
>6v1a Chain C (length=13) Species:
9606
(Homo sapiens) [
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GGYRAtPAKAAAT
Receptor-Ligand Complex Structure
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PDB
6v1a
The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Resolution
2.29 Å
Binding residue
(original residue number in PDB)
Y30 D57 Y60 W61 Q64 L67 K71 T77 Y78 H81 N82 V85
Binding residue
(residue number reindexed from 1)
Y29 D56 Y59 W60 Q63 L66 K70 T76 Y77 H80 N81 V84
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Biological Process
GO:0006955
immune response
GO:0019882
antigen processing and presentation
Cellular Component
GO:0016020
membrane
GO:0042613
MHC class II protein complex
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Biological Process
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Cellular Component
External links
PDB
RCSB:6v1a
,
PDBe:6v1a
,
PDBj:6v1a
PDBsum
6v1a
PubMed
33863750
UniProt
P01911
|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)
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