Structure of PDB 6v18 Chain B Binding Site BS01

Receptor Information
>6v18 Chain B (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVT
ELGRPDAEYWNSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVTV
YPAKLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWTFQTLVM
LETVPRSGEVYTCQVEHPSLTSPLTVEW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v18 The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		H13 Y30 P56 D57 Y60 W61 Q64 L67 K71 T77 Y78 H81 N82 V85
Binding residue
(residue number reindexed from 1)		H12 Y29 P55 D56 Y59 W60 Q63 L66 K70 T76 Y77 H80 N81 V84
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6v18, PDBe:6v18, PDBj:6v18
PDBsum6v18
PubMed33863750
UniProtP01911|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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