Structure of PDB 6urq Chain B Binding Site BS01
Receptor Information
>6urq Chain B (length=307) Species:
9606
(Homo sapiens) [
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KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRI
VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLW
QFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL
TYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLH
PKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKM
NALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEA
VQQILSE
Ligand information
>6urq Chain C (length=8) Species:
9606
(Homo sapiens) [
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RGRGDGQE
Receptor-Ligand Complex Structure
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PDB
6urq
Tissue-Specific Regulation of the Wnt/ beta-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Resolution
2.05 Å
Binding residue
(original residue number in PDB)
R368 S370 G378 Y379 N408 Y412 H414 D432 W434 F436 E441 R447
Binding residue
(residue number reindexed from 1)
R34 S36 G44 Y45 N74 Y78 H80 D98 W100 F102 E107 R113
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:6urq
,
PDBe:6urq
,
PDBj:6urq
PDBsum
6urq
PubMed
32698014
UniProt
O95271
|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)
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