Structure of PDB 6ujc Chain B Binding Site BS01

Receptor Information
>6ujc Chain B (length=359) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLV
DVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIH
PERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTP
EGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPN
DGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKD
LLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNI
TAICPDGSRKPGMEGCRNVTSNDEVLFNVTVTMKKCDNYAIIKPIGFNET
AKIHIHRNC
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6ujc Chain B Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ujc Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Resolution3.56 Å
Binding residue
(original residue number in PDB)		D151 N207 D209 P211 E212
Binding residue
(residue number reindexed from 1)		D90 N146 D148 P150 E151
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0046872 metal ion binding
GO:1990430 extracellular matrix protein binding
Biological Process
GO:0001570 vasculogenesis
GO:0001573 ganglioside metabolic process
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0009615 response to virus
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0045766 positive regulation of angiogenesis
GO:0051216 cartilage development
GO:0060022 hard palate development
GO:0060674 placenta blood vessel development
GO:0061520 Langerhans cell differentiation
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0034686 integrin alphav-beta8 complex
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ujc, PDBe:6ujc, PDBj:6ujc
PDBsum6ujc
PubMed31955848
UniProtP26012|ITB8_HUMAN Integrin beta-8 (Gene Name=ITGB8)

[Back to BioLiP]