Structure of PDB 6uca Chain B Binding Site BS01

Receptor Information
>6uca Chain B (length=393) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLPLDPAVPAPLCPHGPTLLFACSACRDRKDCNFFQWEDEKLSGARLAAR
EAHNRRCQPPLSRTQCVERYLKFIELPLTQRKFCQTCQQLLLPDDWGQHS
EHQVLGNVSITQLRRPSQLLYPLENAATNAQYLFADRSCQFLVDLLSALG
FRRVLCVGTPRLHELIKLTASGDKKSNIKSLLLDIDFRYSQFYMEDSFCH
YNMFNHHFFDGKTALEVCRAFLQEDKGEGIIMVTDPPFGGLVEPLAITFK
KLIAMWKEGQSQDDSHKELPIFWIFPYFFESRICQFFPSFQMLDYQVDYD
NHALYKHRKQSPVRIFTNIPPNKIILPTEEGYRFCSPCQRYVSLENQHCE
LCNSCTSKDGRKWNHCFLCKKCVKPSWIHCSICNHCAVPDHSC
Ligand information
Ligand IDSAH
InChIInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
FormulaC14 H20 N6 O5 S
NameS-ADENOSYL-L-HOMOCYSTEINE
ChEMBLCHEMBL418052
DrugBankDB01752
ZINCZINC000004228232
PDB chain6uca Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6uca Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA.
Resolution3.103 Å
Binding residue
(original residue number in PDB)		N170 A171 Q172 Y173 L174 F175 G199 P201 R202 D225 I226 Y242 N243 M244 F245 D276
Binding residue
(residue number reindexed from 1)		N129 A130 Q131 Y132 L133 F134 G158 P160 R161 D184 I185 Y201 N202 M203 F204 D235
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008988 rRNA (adenine-N6-)-methyltransferase activity
Biological Process
GO:0031167 rRNA methylation
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6uca, PDBe:6uca, PDBj:6uca
PDBsum6uca
PubMed31695039
UniProtQ9H5U6|ZCHC4_HUMAN rRNA N6-adenosine-methyltransferase ZCCHC4 (Gene Name=ZCCHC4)

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