Structure of PDB 6u3e Chain B Binding Site BS01

Receptor Information
>6u3e Chain B (length=397) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGHHHHHHGSPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEI
DNLTSVEESKYTQRNAQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVA
QFLYKGEGLNKTVIGDYLGERDDFNIKVLQAFVELHEFADLNLVQALRQF
LWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNT
SLHNHNVRDKPTAERFITMNRGINEGGDLPEELLRNLYESIKNEPFKIPE
DDGNDLTYTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK
EPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVE
GNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
Ligand information
Ligand ID4IP
InChIInChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2-,3-,4+,5-,6-/m0/s1
InChIKeyCIPFCGZLFXVXBG-CNWJWELYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=P(O)(O)OC1C(O)C(OP(=O)(O)O)C(O)C(OP(=O)(O)O)C1OP(=O)(O)O
OpenEye OEToolkits 1.7.6[C@H]1([C@H](C([C@H]([C@H](C1OP(=O)(O)O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)O
CACTVS 3.385O[CH]1[CH](O[P](O)(O)=O)[CH](O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH]1O[P](O)(O)=O
OpenEye OEToolkits 1.7.6C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)O)OP(=O)(O)O)O
CACTVS 3.385O[C@H]1[C@@H](O[P](O)(O)=O)[C@H](O)[C@@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@H]1O[P](O)(O)=O
FormulaC6 H16 O18 P4
NameINOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
ChEMBLCHEMBL23552
DrugBankDB01863
ZINCZINC000012494830
PDB chain6u3e Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6u3e Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
Resolution53.0 Å
Binding residue
(original residue number in PDB)		K273 G276 R277 V278 T280 K282 R284 Y295 R305 K343 N354 H355
Binding residue
(residue number reindexed from 1)		K271 G274 R275 V276 T278 K280 R282 Y293 R303 K341 N352 H353
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008289 lipid binding
Biological Process
GO:0032012 regulation of ARF protein signal transduction
GO:0045785 positive regulation of cell adhesion
GO:0048193 Golgi vesicle transport
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0000139 Golgi membrane
GO:0001726 ruffle
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005923 bicellular tight junction

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6u3e, PDBe:6u3e, PDBj:6u3e
PDBsum6u3e
PubMed31601460
UniProtO43739|CYH3_HUMAN Cytohesin-3 (Gene Name=CYTH3)

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