Structure of PDB 6u2g Chain B Binding Site BS01

Receptor Information

>6u2g Chain B (length=264) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKN
EVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEM
IKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN
INNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFP
QILASIELLARSLP

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

6u2g Chain B Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6u2g Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.
Resolution	2.886 Å
Binding residue (original residue number in PDB)	N581 D594
Binding residue (residue number reindexed from 1)	N131 D144
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1)	D126 K128 N130 N131 D144 S158
Enzyme Commision number	2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:6u2g, PDBe:6u2g, PDBj:6u2g
PDBsum	6u2g
PubMed	31988522
UniProt	P15056\|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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