Structure of PDB 6trw Chain B Binding Site BS01

Receptor Information
>6trw Chain B (length=834) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEPFYVERYSWSQLKKLLADTRKYHAKAPHDFMFVKRNDPDGPHSDRIYY
LAMSRENTLFYSEIPKTINRAAVLMLSWKPLLDLYSREEELLRERKRIGT
VGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPN
IRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDA
RSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEI
IHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKE
LIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFI
PVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEE
IEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIA
ITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEV
TRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKT
KEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYP
TVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLK
FEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLM
ALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAM
QAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQE
RHSIRVPESGEHYELHLLHYLQENLGSRIAALKV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6trw Aerosol-based ligand soaking of reservoir-free protein crystals.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R160 E275 E276 Y669 W754 S755 Y756 V781 W784 Y787 Y791 H865 S866 I867 R868 E874 Y876
Binding residue
(residue number reindexed from 1)		R97 E212 E213 Y606 W691 S692 Y693 V718 W721 Y724 Y728 H802 S803 I804 R805 E811 Y813
Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y606 S692 Y693 D770 H802
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6trw, PDBe:6trw, PDBj:6trw
PDBsum6trw
PubMed34188616
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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