Structure of PDB 6t2v Chain B Binding Site BS01

Receptor Information
>6t2v Chain B (length=1129) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AETLDPLRLPLQGERLIEASAGTGKTFTIAALYLRLLLGLGGSAAFPRPL
TVEELLVVTFTEAATAELRGRIRSNIHELRIACLRETTDNPLYERLLEEI
DDKAQAAQWLLLAERQMDEAAVFTIHGFCQRMLNLNAFESGMLFEQQLIE
DESLLRYQACADFWRRHCYPLPREIAQVVFETWKGPQALLRDINRYLQGE
APVIKAPPPDDETLASRHAQIVARIDTVKQQWRDAVGELDALIESSGIDR
RKFNRSNQAKWIDKISAWAEEETNSYQLPESLEKFTPRHPLFEAIDQLLA
EPLSIRDLVITRALAEIRETVAREKRRRGELGFDDMLSRLDSALRSESGE
VLAAAIRTRFPVAMIDEFQDTDPQQYRIFRRIWHHQPETALLLIGDPKQA
IYAFRGADIFTYMKARSEVHAHYTLDTNWRSAPGMVNSVNKLFSQTDDAF
MFREIPFIPVKSAGKNQALRFVFKGETQPAMKMWLMEGESCGVGDYQSTM
AQVCAAQIRDWLQAGQRGEALLMNGDDARPVRASDISVLVRSRQEAAQVR
DALTLLEIPSVYLSNRDSVFETLEAQEMLWLLQAVMTPERENTLRSALAT
SMMGLNALDIETLNNDEHAWDVVVEEFDGYRQIWRKRGVMPMLRALMSAR
NIAENLLATAGGERRLTDILHISELLQEAGTQLESEHALVRWLSQHILEP
DSNASSQQMRLESDKHLVQIVTIHKSKGLEYPLVWLPFITNFRVQEQAFY
HDRHSFEAVLDLNAAPESVDLAEAERLAEDLRLLYVALTRSVWHCSLGVA
PLVRRRGDKKGDTDVHQSALGRLLQKGEPQDAAGLRTCIEALCDDDIAWQ
TAQTGDNQPWQVNDVSTAELNAKTLQRLPGDNWRVTSYSGLQPTLTPHQF
PRGASPGTFLHSLFEDLDFTQPVDPNWVREKLELGGFESQWEPVLTEWIT
AVLQAPLNETGVSLSQLSARNKQVEMEFYLPISEPLIASQLDTLIRQFDP
LSAGCPPLEFMQVRGMLKGFIDLVFRHEGRYYLLAYKSNWLGEDSSAYTQ
QAMAAAMQAHRYDLQYQLYTLALHRYLRHRIADYDYEHHFGGVIYLFLRG
VDKEHPQQGIYTTRPNAGLIALMDEMFAG
Ligand information
>6t2v Chain X (length=54) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ttttttttttttgagcgactgcactacaacgttgtagtgcagtcgctctt
tttt
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6t2v A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		L152 D253 R254 Y280 F351 F422 R559 R561 R584 H742 K743 R761 R824
Binding residue
(residue number reindexed from 1)		L148 D249 R250 Y276 F333 F404 R541 R543 R566 H724 K725 R743 R806
Enzymatic activity
Enzyme Commision number 3.1.11.5: exodeoxyribonuclease V.
5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0004520 DNA endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0008854 exodeoxyribonuclease V activity
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0009314 response to radiation
GO:0032508 DNA duplex unwinding
GO:0044355 clearance of foreign intracellular DNA
Cellular Component
GO:0005829 cytosol
GO:0009338 exodeoxyribonuclease V complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t2v, PDBe:6t2v, PDBj:6t2v
PDBsum6t2v
PubMed31907455
UniProtP08394|RECB_ECOLI RecBCD enzyme subunit RecB (Gene Name=recB)

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