Structure of PDB 6t10 Chain B Binding Site BS01

Receptor Information
>6t10 Chain B (length=155) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRS
ARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLGGVFKIDWICRRE
LPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQ
VIHKM
Ligand information
Ligand IDM6Z
InChIInChI=1S/C9H8IN3O/c1-11-9(14)8-6-4-5(10)2-3-7(6)12-13-8/h2-4H,1H3,(H,11,14)(H,12,13)
InChIKeyRJUNKUYOTNQVNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CNC(=O)c1c2cc(ccc2[nH]n1)I
CACTVS 3.385CNC(=O)c1n[nH]c2ccc(I)cc12
FormulaC9 H8 I N3 O
Name5-iodanyl-~{N}-methyl-1~{H}-indazole-3-carboxamide
ChEMBLCHEMBL3467551
DrugBank
ZINCZINC000095962066
PDB chain6t10 Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6t10 Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.
Resolution1.48 Å
Binding residue
(original residue number in PDB)		W377 S378 W428 D476
Binding residue
(residue number reindexed from 1)		W34 S35 W85 D124
Annotation score1
Binding affinityMOAD: ic50=348uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6t10, PDBe:6t10, PDBj:6t10
PDBsum6t10
PubMed32101404
UniProtQ96MU7|YTDC1_HUMAN YTH domain-containing protein 1 (Gene Name=YTHDC1)

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