Structure of PDB 6t0w Chain B Binding Site BS01

Receptor Information
>6t0w Chain B (length=661) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEYS
NKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEHP
GLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSF
RLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGFL
IKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRG
FVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISM
TVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIAR
LGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEG
TASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFV
NAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGF
VSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLF
IADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNL
RNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITKMDYD
AVSGTHSWRTK
Ligand information
>6t0w Chain V (length=25) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguaguaacaagaggccucucugcu
.<<....>>.<<<<..>>>>.....
Receptor-Ligand Complex Structure
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PDB6t0w A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		H32 G33 Y38 N195 M356 K365 E384 Y556 S565 V567 E568
Binding residue
(residue number reindexed from 1)		H32 G33 Y38 N195 M356 K365 E384 Y556 S565 V567 E568
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t0w, PDBe:6t0w, PDBj:6t0w
PDBsum6t0w
PubMed32304664
UniProtQ5V8Y6

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