Structure of PDB 6t0s Chain B Binding Site BS01

Receptor Information
>6t0s Chain B (length=743) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNHSKKMI
TQRTIGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRG
FVYFVELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSY
TITGDNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVAR
LGRGYMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGT
ASLSPGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALI
INGHFKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYG
FVANFSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQL
FIKDYRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYN
LRNLHIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTSLEYDAVATT
HSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYRRPIGMAS
MLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALKRQ
Ligand information
>6t0s Chain V (length=33) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguaguaacaagauuuuuuccgucucuucugcu
.<<....>>........................
Receptor-Ligand Complex Structure
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PDB6t0s A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution3.04 Å
Binding residue
(original residue number in PDB)		H32 G33 T34 R126 Q127 R135 K198 I200 R203 I205 M227 K229 I241 A242 R260 P272 G274 Y355 M356 R365 M414 I525 T528 Y557 T566 N567 L568 E569 R571 H633 M635 T667 I674 L675 N676 E697
Binding residue
(residue number reindexed from 1)		H32 G33 T34 R126 Q127 R135 K198 I200 R203 I205 M227 K229 I241 A242 R260 P272 G274 Y355 M356 R365 M414 I525 T528 Y557 T566 N567 L568 E569 R571 H633 M635 T654 I661 L662 N663 E684
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t0s, PDBe:6t0s, PDBj:6t0s
PDBsum6t0s
PubMed32304664
UniProtH6QM91

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