Structure of PDB 6sz3 Chain B Binding Site BS01

Receptor Information
>6sz3 Chain B (length=164) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRS
ARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVF
KIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFP
PDESIDLYQVIHKM
Ligand information
Ligand IDM1H
InChIInChI=1S/C10H14N2/c1-11-9-6-7-12-10-5-3-2-4-8(9)10/h6-7H,2-5H2,1H3,(H,11,12)
InChIKeyKZFXOHUERSGRGX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CNc1ccnc2c1CCCC2
CACTVS 3.385CNc1ccnc2CCCCc12
FormulaC10 H14 N2
Name~{N}-methyl-5,6,7,8-tetrahydroquinolin-4-amine
ChEMBL
DrugBank
ZINCZINC000221030809
PDB chain6sz3 Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6sz3 Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.
Resolution1.28 Å
Binding residue
(original residue number in PDB)		S378 T379 L380 W428 M434
Binding residue
(residue number reindexed from 1)		S35 T36 L37 W85 M91
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6sz3, PDBe:6sz3, PDBj:6sz3
PDBsum6sz3
PubMed32101404
UniProtQ96MU7|YTDC1_HUMAN YTH domain-containing protein 1 (Gene Name=YTHDC1)

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