Structure of PDB 6sk3 Chain B Binding Site BS01

Receptor Information
>6sk3 Chain B (length=390) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLP
QGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRP
PGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKK
LRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNP
RKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLL
TRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTL
PSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNAL
DLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGL
Ligand information
Receptor-Ligand Complex Structure
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PDB6sk3 High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Y180 D183 D185 F188 F190 N246 T282 Y296 H298 F311 H313 S405 I469 G470 D471 G472 N473
Binding residue
(residue number reindexed from 1)		Y77 D80 D82 F85 F87 N143 T179 Y193 H195 F208 H210 S302 I366 G367 D368 G369 N370
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6sk3, PDBe:6sk3, PDBj:6sk3
PDBsum6sk3
PubMed32111831
UniProtP30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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