Structure of PDB 6siv Chain B Binding Site BS01

Receptor Information
>6siv Chain B (length=136) Species: 333760 (Human papillomavirus 16) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFARRDLCIVYRDG
NPYAVCDKCLKFYSKISEYRHYSYSLYGTTLEQQYNKPLSDLLIRCINCQ
KPLSPEEKQRHLDKKQRFHNIRGRWTGRCMSCSRSS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6siv Chain B Residue 1200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6siv Deciphering the molecular and structural interaction between IRF3 and HPV16 E6
Resolution1.752 Å
Binding residue
(original residue number in PDB)		C1103 C1106 C1136 C1139
Binding residue
(residue number reindexed from 1)		C96 C99 C129 C132
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0019049 virus-mediated perturbation of host defense response
GO:0030162 regulation of proteolysis
GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
GO:0039648 symbiont-mediated perturbation of host ubiquitin-like protein modification
GO:0039653 symbiont-mediated suppression of host transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0052150 symbiont-mediated perturbation of host apoptosis
GO:0090630 activation of GTPase activity
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6siv, PDBe:6siv, PDBj:6siv
PDBsum6siv
PubMed
UniProtP03126|VE6_HPV16 Protein E6 (Gene Name=E6)

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