Structure of PDB 6sad Chain B Binding Site BS01
Receptor Information
>6sad Chain B (length=233) Species:
9606
(Homo sapiens) [
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VDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKN
VVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVL
SLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSE
KAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAF
DDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWT
Ligand information
>6sad Chain C (length=19) Species:
9606
(Homo sapiens) [
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DYDLSLPFPVCESCEHSLD
Receptor-Ligand Complex Structure
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PDB
6sad
14-3-3 protein binding blocks the dimerization interface of caspase-2.
Resolution
2.753 Å
Binding residue
(original residue number in PDB)
E15 K50 R57 R61 R132 Y133 L177 N178 V181 I222 N229
Binding residue
(residue number reindexed from 1)
E14 K49 R56 R60 R131 Y132 L176 N177 V180 I221 N228
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003723
RNA binding
GO:0005080
protein kinase C binding
GO:0005159
insulin-like growth factor receptor binding
GO:0005515
protein binding
GO:0008426
protein kinase C inhibitor activity
GO:0019904
protein domain specific binding
GO:0030971
receptor tyrosine kinase binding
GO:0042802
identical protein binding
GO:0140031
phosphorylation-dependent protein binding
GO:0140311
protein sequestering activity
Biological Process
GO:0002842
positive regulation of T cell mediated immune response to tumor cell
GO:0006469
negative regulation of protein kinase activity
GO:0006605
protein targeting
GO:0007165
signal transduction
GO:0008104
protein localization
GO:0009966
regulation of signal transduction
GO:0022409
positive regulation of cell-cell adhesion
GO:0032869
cellular response to insulin stimulus
GO:0032880
regulation of protein localization
GO:0042149
cellular response to glucose starvation
GO:0045664
regulation of neuron differentiation
GO:0048167
regulation of synaptic plasticity
GO:0050870
positive regulation of T cell activation
GO:1904262
negative regulation of TORC1 signaling
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005925
focal adhesion
GO:0016020
membrane
GO:0031982
vesicle
GO:0045202
synapse
GO:0070062
extracellular exosome
GO:0098793
presynapse
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:6sad
,
PDBe:6sad
,
PDBj:6sad
PDBsum
6sad
PubMed
31961068
UniProt
P61981
|1433G_HUMAN 14-3-3 protein gamma (Gene Name=YWHAG)
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