Structure of PDB 6s1u Chain B Binding Site BS01

Receptor Information

>6s1u Chain B (length=106) Species: 11855 (Mason-Pfizer monkey virus)

WVQPITAQKPSLTLWLDDKMFTGLINTGADVTIIKLEDWPPNWPITDTLT
NLRGSNNPKQSSKYLTWRDKENNSGLIKPFVIPNLPVNLWGRDLLSQMKI
MMASPN

Ligand information

>6s1u Chain I (length=7) Species: 32630 (synthetic construct)

PYVYAMT

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6s1u Comparison of a retroviral protease in monomeric and dimeric states.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): N26 G28 D30 I33 R53 P89 L92
• Binding residue (residue number reindexed from 1): N26 G28 D30 I33 R53 P86 L89

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-
  3.6.1.23: dUTP diphosphatase.

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6s1u, PDBe:6s1u, PDBj:6s1u
• PDBsum: 6s1u
• PubMed: 31588922
• UniProt: P07572|POL_MPMV Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)