Structure of PDB 6ru7 Chain B Binding Site BS01

Receptor Information
>6ru7 Chain B (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIE
SKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGL
AKKYRDQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYF
NLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCR
SLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
Ligand information
Receptor-Ligand Complex Structure
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PDB6ru7 p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Resolution2.08 Å
Binding residue
(original residue number in PDB)		R127 D128 K130 G151 L152 A153 T174 G175 T176 R178 Q214 K224 Y225
Binding residue
(residue number reindexed from 1)		R125 D126 K128 G149 L150 A151 T168 G169 T170 R172 Q208 K218 Y219
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ru7, PDBe:6ru7, PDBj:6ru7
PDBsum6ru7
PubMed32719556
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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