Structure of PDB 6rrq Chain B Binding Site BS01

Receptor Information

>6rrq Chain B (length=448) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PQTPDEASLDLAATDGIRLGDRLRGLWDLRLVGGDAELPGLPREGLQLVL
DVAPKGRGLIGYLDTPERLLAAEPPRFRVLGDLLGASSASIRWRLVDQAS
GSVAPTHDCSAVFDEDGTLSGRIQRLERSEDFRFVAVKRHFPLAHERIVL
NEKLLGWLVSPQHRLFHQLWHASRDKWHRLSEKQRNALRGVGWQPGPLDR
ERDARGPRKDRNASGIDFFFMHRHMLHTARSMQDLPSWERLPRPVVPLEY
DRPGFIRYFDNPDGFSVPPAWVAVDDDEYSEWLHGLKSAEAYHANFLVWE
SQYQDPAYLAKLTLGQFGSELELGMHDWLHMRWASVTRDPSMTDRFPADF
APRWFRPENDFLGDPFSSHVNPVFWSFHGWIDDRIEDWYRAHERFHPGEV
QRREVEGIQWFAPGRWVEVGDPWLGPATHGSVELDVETMKLALRIIFS

Ligand information

Ligand ID

InChI

InChI=1S/Cu/q+2

InChIKey

JPVYNHNXODAKFH-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Cu+2]
CACTVS 3.341	[Cu++]

Formula

Name

COPPER (II) ION

PDB chain

6rrq Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6rrq A novel mechanism of inhibition by phenylthiourea on PvdP, a tyrosinase synthesizing pyoverdine of Pseudomonas aeruginosa.
Resolution	2.7 Å
Binding residue (original residue number in PDB)	H216 H220 H271
Binding residue (residue number reindexed from 1)	H167 H171 H222
Annotation score	3

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004503	tyrosinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0002049	pyoverdine biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:6rrq, PDBe:6rrq, PDBj:6rrq
PDBsum	6rrq
PubMed	31899238
UniProt	Q9I188

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