Structure of PDB 6rie Chain B Binding Site BS01

Receptor Information
>6rie Chain B (length=1129) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMDQRLGYKFLVPDPKAGVFYRPLHFQYVSYSNFILHRLHEILTVKRPLL
SFKNNTERIMIEISNVKVTPPDYSPIIASIKGKSYDALATFTVNIFKEVM
TKEGISITKISSYEGLIKIPLLIGYGNKNPLDTAKYLVPNVIGGVFINKQ
SVEKVGINLVEKITTWPKFRVVKPNSFTFSFSSVSPPNVLPTRYRHYKIS
LDISQLEALNISSTKTFITVNIVLLSQYLSRVSLEFIRRSLSYDMPPEVV
YLVNAIIDSAKRITESITDFNIDTYINDLVEAEHIKQKSQLTINEFKYEM
LHNFLPHMNYTPDQLKGFYMISLLRKFLYCIFHTSRYPDRDSMVCHRILT
YGKYFETLAHDELENYIGNIRNDIMNNHKNRGTYAVNIHVLTTPGLNHAF
SSLLSGKFKKSDGSYRTHPHYSWMQNISIPRSVGFYPSVRKYHPSQYLYF
CSSDVPERGPQVGLVSQLSVLSSITNILTSEYLDLEKKICEYIRSYYKDD
ISYFETGFPITIENALVASLNPNMICDFVTDFRRRKRMGFFGNLEVGITL
VRDHMNEIRINIGAGRLVRPFLVVDNGELMMDVCPELESRLDDMTFSDIQ
KEFPHVIEMVDIEQFTFSNVCESVQKFRMMSKDERKQYDLCDFPAEFRDG
YVASSLVGINHNSGPRAILGCAQAKQAISCLSSDIRNKIDNGIHLMYPER
PIVISKALETSKIAANCFGQHVTIALMSYKGINQEDGIIIKKQFIQRGGL
DIVTAKKHQVEIPLENFNNKERDRSNAYSKLESNGLVRLNAFLESGDAMA
RNISSSFDVSEKYTDMYKSRVERVQVELTDKVKVRVLTMKERRPILGDKF
TTRTSQKGTVAYVADETELPYDENGITPDVIINSTSIFSRKTISMLIEVI
LTAAYSAKPYNNKGENRPVCFPSSNETSIDTYMQFAKQCYEHSNPKLSDE
ELSDKIFCEKILYDPETDKPYASKVFFGPIYYLRLRHLTQDKATVRCRGK
KTKLIRQANEGRKRGGGIKFGEMERDCLIAHGAANTITEVLKDSEEDYQD
VYVCENCGDIAAQIKGINTCLRCSKLNLSPLLTKIDTTHVSKVFLTQMNA
RGVKVKLDFERRPPSFYKPLDKVDLKPSF
Ligand information
Receptor-Ligand Complex Structure
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PDB6rie Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y432 R478 Q481 Q696 D841 V842 K882 K890 H1020 K1033
Binding residue
(residue number reindexed from 1)		Y421 R458 Q461 Q676 D808 V809 K849 K857 H987 K1000
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rie, PDBe:6rie, PDBj:6rie
PDBsum6rie
PubMed31835031
UniProtQ76ZP7|RP132_VACCW DNA-directed RNA polymerase 133 kDa polypeptide (Gene Name=OPG151)

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