Structure of PDB 6r7x Chain B Binding Site BS01

Receptor Information
>6r7x Chain B (length=629) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQE
TLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFD
DNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLL
TSGIVIQVFPLHDSEALKKLEDTWYTRFALKYQPIDSIRGYFGETIALYF
GFLEYFTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWK
RGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQL
RIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVP
SIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNC
FASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVR
VKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFS
CVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETM
SVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFA
IPDKPRHIQMKLARLEFESLEALKQQQMK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6r7x Chain B Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6r7x The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Resolution3.47 Å
Binding residue
(original residue number in PDB)		N444 Q445 E448 E500 E529
Binding residue
(residue number reindexed from 1)		N432 Q433 E436 E488 E517
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r7x, PDBe:6r7x, PDBj:6r7x
PDBsum6r7x
PubMed31477691
UniProtQ9NW15|ANO10_HUMAN Anoctamin-10 (Gene Name=ANO10)

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