Structure of PDB 6r51 Chain B Binding Site BS01

Receptor Information

>6r51 Chain B (length=196) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HMDSTTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKYLNALKQ
NNLKIKLLSGKLTDEKEYAYLKGVVPKGWEGTGKTWDDVPGLGGSTVALR
IGFSNKGKGHDAINLELHATAHAIDHIVLNDISKSAQFKQIFAKEGRSLG
NVNFLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK

Ligand information

>6r51 Chain E (length=7) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SLRPAPP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6r51 Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
Resolution	1.94 Å
Binding residue (original residue number in PDB)	K101 W103 W110 G115 L116 G117 G118 S119 H134 D135 H142 H146 H150 F178 E185
Binding residue (residue number reindexed from 1)	K77 W79 W86 G91 L92 G93 G94 S95 H110 D111 H118 H122 H126 F154 E161

Enzymatic activity

Enzyme Commision number

3.4.24.89: Pro-Pro endopeptidase.

Gene Ontology

	Molecular Function
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0005576	extracellular region

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External links

PDB	RCSB:6r51, PDBe:6r51, PDBj:6r51
PDBsum	6r51
PubMed	31182482
UniProt	Q183R7\|PPEP1_CLOD6 Pro-Pro endopeptidase (Gene Name=zmp1)

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